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Dihexa works through an entirely novel mechanism by potentiating hepatocyte growth factor at the c-Met receptor, a pathway involved in synapse formation rather than traditional neurotransmitter modulation

The side effect profile of retatrutide is broadly similar to semaglutide and tirzepatide side effects , though the glucagon receptor component can cause additional symptoms in some users

Adverse hepatic outcomes related to NASH may include cirrhosis, liver failure and hepatocellular carcinoma, whereas non-liver-associated adverse outcomes are primarily related to increased cardiovascular disease and malignancy12,13

Additionally, most mechanistic studies rely on animal models, raising concerns about translatability to humans due to interspecies differences in GLP-1R distribution and signaling (Drucker, 2022)